Q41

Describe the pharmacokinetics of ciprofloxacin.
Prompt: Which patients will need a dose adjustment?

  • PO or IV
  • PO bioavailability >80%
  • 20 – 40% is protein bound
  • Elimination half-life is 3 – 5 hours
  • Doses:
    • PO: 250 – 500 mg BD (max 1.5 grams)
    • IV: 200 – 300 mg BD (max 1.2 grams)
    • Renal elimination – dose needs to be adjusted if CrCl <50 mL/min

Pass Criteria:

  • Bold to pass.

Describe its mechanism of action.

Blocks DNA synthesis by inhibiting bacterial topoisomerase II (DNA gyrase) and  prevents normal transcription and replication.

Pass Criteria:

  • Bold to pass.

What is its antimicrobial spectrum?

Excellent Gram negative activity and moderate Gram positive activity:

  • S. aureus
  • Mycoplasma
  • Chlamydia sp
  • Legionella
  • Pseudomonas
  • Mycobacterium
  • Anthrax

Pass Criteria:

  • Bold to pass.

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